TY  - EJOU
AU  - VANASCO, Virginia 
AU  - MARCHINI, Timoteo 
AU  - MAGNANI, Natalia 
AU  - VICO, Tamara 
AU  - GARCES, Mariana 
AU  - CACERES, Lourdes 
AU  - GUAGLIANONE, Alejandro 
AU  - EVELSON, Pablo 
AU  - ALVAREZ., Silvia 

TI  - The role of mitochondria in inflammatory syndromes
T2  - BIOCELL

PY  - 2016
VL  - 40
IS  - 1
SN  - 1667-5746

AB  - Several authors have addressed the importance of mitochondrial function in inflammatory syndromes, as it may play a role in the genesis of tissue injury. Sepsis and exposition to environmental particles are
examples of inflammatory conditions. Sepsis occurs with an exacerbated inflammatory response that damages
tissue mitochondria and impairs bioenergetic processes. One of the current hypotheses for the molecular mechanisms underlying the complex condition of sepsis is that enhanced NO production and oxidative stress lead to
mitochondrial dysfunction, bioenergetic derangement and organ failure. The mechanism of particulate matter-health effects are believed to involve inflammation and oxidative stress. Components in particles that elicit
inflammation have been poorly investigated, although recent research points out to the contribution of compositional elements and particle size. Oxygen metabolism and mitochondrial function appear to be important areas
of study in inflammatory conditions for clarifying molecular mechanisms involved.
KW  - mitochondrial function
KW  -  bioenergetics
KW  -  heart
KW  -  endotoxemia
KW  -  ambient air particles

DO  - 10.32604/biocell.2016.40.047