@Article{biocell.2018.04615,
AUTHOR = {Hong YE, WeiWei Wang, Yu Ding, XiaoLei Liu, WenJI Jia, WeiLi Luo, HuiJuan Fan, HongQun Zhou, Jin Wang, JianLong Ju, DongMing Zhou, TianHao Bao, YuHong Zhu},
TITLE = {Spontaneous running wheel improves neuroprotection efficacy of ischemic postconditioning in mice following ischemia/reperfusion injury},
JOURNAL = {BIOCELL},
VOLUME = {42},
YEAR = {2018},
NUMBER = {3},
PAGES = {79--86},
URL = {http://www.techscience.com/biocell/v42n3/33749},
ISSN = {1667-5746},
ABSTRACT = {Ischemic postconditioning (IP) has been shown to provide protection for ischemia/reperfusion (IR)
injury, but its efficacy is limited. In this study we hypothesized that spontaneous running wheel (RW) could improve
neuroprotection efficacy of IP for IR. We established mouse models of IR and showed that compared to Sham group,
IR group had obvious brain infract and neurological dysfunction. In IR+IP group, brain infract and neurological
dysfunction improved compared to IR group. However, in IR+IP+RW group brain infract and neurological dysfunction
improved much better. TUNEL assay showed that IP but not RW significantly reduced the number of apoptotic cells
after IR. However, the number of apoptotic cells was significantly reduced in RW+IP group. In addition, the levels of
pro-apoptotic factors increased in IR group but significantly reduced in IR+IP+RW group, while the levels of antiapoptotic factors decreased in IR group but significantly increased in IR+IP+RW group. Moreover, in IR+IP+RW
group, MDA level was further decreased and SOD level was further increased compared to IR+IP group. Finally, both
PI3K inhibitor and STAT3 inhibitor significantly worsened brain infract and neurological dysfunction and promoted
apoptosis in IR mice. In conclusion, RW combined with IP reduces brain infract and neurological dysfunction in mice
after IR, and this is associated with enhanced anti-apoptotic and anti-oxidant benefits via the activation of PI3K and
STAT3 pathways.},
DOI = {10.32604/biocell.2018.04615}
}