TY  - EJOU
AU  - EBRAHIM, Nesrine 
AU  - EHSAN, Eman 
AU  - GHANY, Eman Abd EL 
AU  - SABRY, Dina 
AU  - SHAMAA, Ashraf 

TI  - Mesenchymal stem cells transplantation attenuates experimentally induced brain injury after neonatal hypoxia by different two routes of administrations
T2  - BIOCELL

PY  - 2019
VL  - 43
IS  - 1
SN  - 1667-5746

AB  -  The neonatal hypoxic–ischemic encephalopathy (HIE) is an important cause of neurological morbidity and
mortality in neonates. Cell therapy is considered a promising method for treating severe neurological disorders such as
this one. Stem cells have the capacity for self-renewal and differentiation into certain cell lineages. The present study was
aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells (BMSCs) administration
for the attenuation of experimentally induced HIE in neonatal rats. Sixty neonatal rats were divided randomly into
four groups. Group 1: control group. Group 2: rats were exposed to bilateral ligation of cephalic arteries. Group 3: rats
were exposed to bilateral ligation of cephalic arteries and then underwent intravenous (IV) BMSC injection. Group 4:
rats were exposed to bilateral ligation of cephalic arteries and then underwent intracerebroventricular (ICV) BMSC
injection. The animals were evaluated by (a) neurobehavioral tests; (b) histopathology, i.e., histological and immunohistochemical studies; and (3) gene expression studies. The BMSC treated groups (3 and 4) showed improvement in
neurobehavioral tests, histopathological studies, and gene expression, as compared to non-injected lesioned rats (Group
2) with better improvement in Group 4 (ICV injections) than in Group 3 (IV injections).
KW  - Cerebral cortex
KW  -  Neonatal hypoxic ischemia
KW  -  Stem cells

DO  - 10.32604/biocell.2019.06111