@Article{biocell.2019.04790,
AUTHOR = {Odin RAMÍREZ-FERNÁNDEZ, Ludovika CACOPARDO, Benjamín LEON-MANCILLA, Joana COSTA},
TITLE = {Design and development of a dual-flow bioreactor mimicking intestinal peristalsis and permeability in epithelial tissue barriers for drug transport assessment},
JOURNAL = {BIOCELL},
VOLUME = {43},
YEAR = {2019},
NUMBER = {1},
PAGES = {29--36},
URL = {http://www.techscience.com/biocell/v43n1/33355},
ISSN = {1667-5746},
ABSTRACT = {We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic
nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed
presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment
of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine
model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor
can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy with
the previously described in vitro small intestinal models, providing a more representative model of the small intestine.},
DOI = {10.32604/biocell.2019.04790}
}