@Article{biocell.2019.07664,
AUTHOR = {Yuan LI, Yonghyun LEE, Yielhea SEO, Youjin HWANG},
TITLE = {Relationship of multidrug-resistant gene and extended-spectrum carbapenem-resistance in <i>Staphylococcus aureus</i>},
JOURNAL = {BIOCELL},
VOLUME = {43},
YEAR = {2019},
NUMBER = {4},
PAGES = {263--269},
URL = {http://www.techscience.com/biocell/v43n4/38126},
ISSN = {1667-5746},
ABSTRACT = {The aim of this study was to determine the relationship between phenotypic antimicrobial susceptibility
patterns and extended-spectrum, carbapenem-resistance genes. A total of 109 clinical <i>Staphilococcus aureus</i> strains were
subjected to 19 antimicrobial susceptibility tests. Resistance to methicillin (mecA), penicillin (blaTEM), and tetracycline
(tetM) was detected. We compared the presence of the blaTEM genes with extended-spectrum, carbapenem-related
genes and identified the types of SCCmec genes. Of 109 clinical <i>S. aureus strains</i>, 62 (56.88%) had methicillin resistance
and 60 strains carried mecA. The prevalence of blaTEM and tetM genes was 81.65% and 37.61%, respectively. The most
predominant SCCmec type was SCCmec type II 28/60 (46.67%), in 60 mecA-positive methicillin-resistant S. aureus
(MRSA) isolates. The SCCmec prevalence rates were type IVA 30.00% (18/60), type IVb 8.33% (5/60), type IVd 6.67%
(4/60), and non-typable 8.33% (5/60). Sixty of the 109 (55.05%) MRSA isolates were positive for extended-spectrum
carbapenems (31/60) (51.67%), cephalosporins 40/60 (66.67%) and carbapenems 31/60 (51.67%). The predominant
SCCmec type II demonstrated more carbapenem-resistance than the IVA, IVb and IVd types.},
DOI = {10.32604/biocell.2019.07664}
}