TY  - EJOU
AU  - LI, Yuan 
AU  - LEE, Yonghyun 
AU  - SEO, Yielhea 
AU  - HWANG, Youjin 

TI  - Relationship of multidrug-resistant gene and extended-spectrum carbapenem-resistance in <i>Staphylococcus aureus</i>
T2  - BIOCELL

PY  - 2019
VL  - 43
IS  - 4
SN  - 1667-5746

AB  - The aim of this study was to determine the relationship between phenotypic antimicrobial susceptibility
patterns and extended-spectrum, carbapenem-resistance genes. A total of 109 clinical <i>Staphilococcus aureus</i> strains were
subjected to 19 antimicrobial susceptibility tests. Resistance to methicillin (mecA), penicillin (blaTEM), and tetracycline
(tetM) was detected. We compared the presence of the blaTEM genes with extended-spectrum, carbapenem-related
genes and identified the types of SCCmec genes. Of 109 clinical <i>S. aureus strains</i>, 62 (56.88%) had methicillin resistance
and 60 strains carried mecA. The prevalence of blaTEM and tetM genes was 81.65% and 37.61%, respectively. The most
predominant SCCmec type was SCCmec type II 28/60 (46.67%), in 60 mecA-positive methicillin-resistant S. aureus
(MRSA) isolates. The SCCmec prevalence rates were type IVA 30.00% (18/60), type IVb 8.33% (5/60), type IVd 6.67%
(4/60), and non-typable 8.33% (5/60). Sixty of the 109 (55.05%) MRSA isolates were positive for extended-spectrum
carbapenems (31/60) (51.67%), cephalosporins 40/60 (66.67%) and carbapenems 31/60 (51.67%). The predominant
SCCmec type II demonstrated more carbapenem-resistance than the IVA, IVb and IVd types.
KW  - MRSA
KW  -  BlaTEM
KW  -  BlaNDM
KW  -  CCmec type II
KW  -  Type IVA
KW  -  Extended-spectrum carbapenems

DO  - 10.32604/biocell.2019.07664