@Article{biocell.2019.08177,
AUTHOR = {Wei LI, Huihui GAO, Ran TAO, Lifang LIU, Shiqiang SHANG},
TITLE = {Association of TRIM22 with the type 1 interferon response during primary human cytomegalovirus infection in THP-1 macrophages},
JOURNAL = {BIOCELL},
VOLUME = {43},
YEAR = {2019},
NUMBER = {4},
PAGES = {285--291},
URL = {http://www.techscience.com/biocell/v43n4/38128},
ISSN = {1667-5746},
ABSTRACT = {As a response factor of interferon, tripartite motif (TRIM) 22 was reported to exert antiviral activity against
viruses. In this study, THP-1 macrophages were infected with human cytomegalovirus (HCMV) to establish the HCMV
lytic infection model. The mRNA levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and interferonbeta
(IFN-β) were significantly up-regulated in THP-1 macrophages at different infection time and titers. Moreover,
for the first time, upregulation of TRIM22 expression was found during HCMV infection at both mRNA and protein
levels in THP-1 macrophages. Furthermore, IFN-β could induce TRIM22 expression in THP-1 macrophages or HCMV
infected THP-1 macrophages. Depletion of TRIM22 increased replication activity of HCMV with increasing of HCMV
titers and HCMV proteins. In conclusion, it is the first report that HCMV can induce TRIM22 activation through
IFN-β signaling and TRIM22 can suppress replication of HCMV in THP-1 macrophages.},
DOI = {10.32604/biocell.2019.08177}
}