@Article{biocell.2020.07593,
AUTHOR = {Xihe TANG, Meigang YU, Rui HUANG, Shengyong LAN; Yimin FAN},
TITLE = {Comparative characterization of human fetal neural stem cells and induced neural stem cells from peripheral blood mononuclear cells},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {1},
PAGES = {13--18},
URL = {http://www.techscience.com/biocell/v44n1/38420},
ISSN = {1667-5746},
ABSTRACT = {Human-induced neural stem cells (iNSCs) transplantation is a potential treatment of neurodegeneration
diseases. However, whether the reprogrammed cells have the same characterizations as human fetal neural stem cells
needs further exploration. Here we isolated human fetal neural stem cells from aborted 12-week fetal brains and
compared with iNSCs reprogrammed from human peripheral blood mononuclear cells in gene expression, proliferation
ability, differentiation capacity, and the responses to tumor necrosis factor-α. We found that iNSCs and NSCs both
expressed neural stem cell markers Nestin, SOX1, and SOX2. However, only iNSCs can be patterned into dopaminergic
neurons and motor neurons. Furthermore, both iNSCs and NSCs can differentiate into oligodendrocyte progenitor
cells. In addition, a low dose of tumor necrosis factor-α did not inhibit the proliferation and differentiation of iNSCs
and NSCs. In conclusion, iNSCs have properties similar to, and even better than, fetal neural stem cells and may be
suitable for disease modeling and transplantation.},
DOI = {10.32604/biocell.2020.07593}
}