@Article{biocell.2020.08613,
AUTHOR = {Wensong LIU, Yunjie LU, Dong ZHANG, Longqing SHI, Guangchen ZU, Haijiao YAN, Donglin SUN},
TITLE = {MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {1},
PAGES = {73--80},
URL = {http://www.techscience.com/biocell/v44n1/38426},
ISSN = {1667-5746},
ABSTRACT = {Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high mortality.
Recent studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic
cancer. In this study, we found that miR-708 was significantly downregulated in pancreatic cancer tissues and cell
lines. Lentivirus-mediated overexpression of miR-708 could significantly inhibit the proliferation and invasion, while
enhanced chemosensitivity to gemcitabine in both Panc-1 and SW1990 cells. Luciferase reporter assay showed that
miR-708 bound the 3’-untranslated region of survivin and suppressed the expression of survivin in pancreatic cancer
cells. In pancreatic cancer tissues, survivin protein was highly expressed and negatively correlated with miR-708
expression. Furthermore, the restoration of survivin expression could partially antagonize proliferation inhibition
and apoptosis induction by miR-708 in pancreatic cancer cells. The Panc-1 cells with overexpression of miR-708 also
showed decreased proliferation capability in nude mouse model compared with parental cells. In conclusion, our results
suggest that miR-708 inhibits pancreatic cancer and could be a novel potential candidate to treat pancreatic cancer.},
DOI = {10.32604/biocell.2020.08613}
}