@Article{biocell.2020.08500,
AUTHOR = {KHAWAR ALI SHAHZAD, ZHONGJIE QIN, YAN LI, DELIN XIA},
TITLE = {The roles of focal adhesion and cytoskeleton systems in fluid shear stress-induced endothelial cell response},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {2},
PAGES = {137--145},
URL = {http://www.techscience.com/biocell/v44n2/39264},
ISSN = {1667-5746},
ABSTRACT = {Focal adhesions are polyproteins linked to extracellular matrix and cytoskeleton, which play an important role
in the process of transforming force signals into intracellular chemical signals and subsequently triggering related
physiological or pathological reactions. The cytoskeleton is a network of protein fibers in the cytoplasm, which is
composed of microfilaments, microtubules, intermediate filaments, and cross-linked proteins. It is a very important
structure for cells to maintain their basic morphology. This review summarizes the process of fluid shear stress
transduction mediated by focal adhesion and the key role of the cytoskeleton in this process, which focuses on the
focal adhesion and cytoskeleton systems. The important proteins involved in signal transduction in focal adhesion are
introduced emphatically. The relationship between focal adhesion and mechanical transduction pathways are
discussed. In this review, we discuss the relationship between fluid shear stress and associated diseases such as
atherosclerosis, as well as its role in clinical research and drug development.},
DOI = {10.32604/biocell.2020.08500}
}