@Article{biocell.2020.08648,
AUTHOR = {EUN NA, MYOUNGWON CHOI, INDAL PARK, SUNYOUNG LIM},
TITLE = {Effect of Black Sea bream extracts on cytokine production in lipopolysaccharide-induced inflammation},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {2},
PAGES = {193--199},
URL = {http://www.techscience.com/biocell/v44n2/39270},
ISSN = {1667-5746},
ABSTRACT = {We investigated the effect of black sea bream extracts on changes in pro-inflammatory and anti-inflammatory
cytokines induced by lipopolysaccharide (LPS) in murine splenocytes. The levels of pro-inflammatory cytokines
[interleukin (IL)-6, tumor necrosis factor-α (TNF-α), IL-12/IL-23(p40) and IL-17A] and anti-inflammatory cytokines
[IL-4, IL-10 and interferon-γ (IFN-γ)] were assessed. Incubation of murine splenocytes with acetone+methylene
chloride (A+M) and methanol (MeOH) extracts significantly decreased LPS-induced IL-6, IL-12/IL-23(p40) and
IL-17A productions after 6 h incubation (p < 0.05). The A+M and MeOH extracts significantly increased LPS-induced
IL-4 and IFN-γ productions at 48 and 72 h incubation (p < 0.05). Treatment with A+M extract resulted in
significantly higher IL-10 production in splenocytes after 72 h (p < 0.05). Conclusively, black sea bream extracts were
shown to be efficient in falling several pro-inflammatory cytokines while rising anti-inflammatory cytokines. Thus our
results suggest that black sea bream extracts selectivity modulate immune events.},
DOI = {10.32604/biocell.2020.08648}
}