@Article{biocell.2020.08714,
AUTHOR = {LEI ZHONG, LEI GUO, ZHISHUAI YE, SHANFENG ZHANG, RONGCHONG HUANG},
TITLE = {Exogenous dendritic cells aggravate atherosclerosis via P-selectin/ PSGL-1 pathway},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {2},
PAGES = {225--236},
URL = {http://www.techscience.com/biocell/v44n2/39274},
ISSN = {1667-5746},
ABSTRACT = {Studies have found that a large number of inflammatory cells, P-selectin, and mature dendritic cells (DCs) are
expressed in the damaged and shoulder parts of atherosclerotic plaque, which demonstrates that P-selectin and mature
DCs participate in the immune inflammatory response leading to the development of atherosclerosis. However, it is
unclear how the above factors interact in this setting. In this study, we investigated the role of P-selectin and its
receptor, P-selectin glycoprotein ligand (PSGL)-1 in atherosclerosis, with the finding that DC surface marker
expression was consistently high in the P-selectin group while consistently low in the PGSL-1 + DCs group, with
CD40 and CD86 expressed by 3.84% and 2.05% for the latter. The highest expression of CD80, CD83, and MHC II
was discovered in the DC group, at 7.49%, 3.68%, and 8.98%, respectively. Results of this study are similar to those
obtained previously by <i>Ye et al.</i> (2017), which showed larger atherosclerotic lesions in mice that received exogenous
DCs, compared with those treated with PBS. In this study, the greatest level of atherosclerosis, fibrosis, and lipid
deposition was also seen in mice that received exogenous DCs.},
DOI = {10.32604/biocell.2020.08714}
}