@Article{biocell.2020.08887,
AUTHOR = {YAQUN HONG, BO WAN, XIAOFAN LI},
TITLE = {Age-related modifications of macrophages influenced by “inflammageing” in graft <i>vs.</i> host disease},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {2},
PAGES = {237--246},
URL = {http://www.techscience.com/biocell/v44n2/39275},
ISSN = {1667-5746},
ABSTRACT = {Most studies focus on the adaptive immune cells in the GVHD pathogenesis, while little is known about innate
immune cells in GVHD occurrence and development, especially macrophages. Meanwhile, a higher incidence of graft
versus host disease (GVHD) is also found in the elderly patients. Though advances have been made in the
modification of macrophages influenced by the inflamm-ageing, there is still no review on the role of macrophages in
GVHD and the association between GVHD and the altered macrophages by inflamm-ageing. In this review, we focus
on the potential age-related modifications of macrophage in GVHD, which contributes to the change of morbidity
and mortality of GVHD. Via literature review, we found that the infiltration of macrophages is associated with
GVHD and macrophages are modified in inflamm-ageing state, including the proliferation, migration, phagocytosis,
antigen presentation, interaction with other immune cells, and pro-fibrosis. We suppose that altered macrophage
functions in inflamm-ageing state contribute to GVHD in elderly patients.},
DOI = {10.32604/biocell.2020.08887}
}