@Article{biocell.2020.011470,
AUTHOR = {MEHMET TASPINAR, ALIHAN BOZOGLAN, ABDULLAH SECKIN ERTUGRUL, LEVENT ELMAS},
TITLE = {The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {3},
PAGES = {337--344},
URL = {http://www.techscience.com/biocell/v44n3/40233},
ISSN = {1667-5746},
ABSTRACT = {This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis
based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is
the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a
considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20
patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with
chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in
the gingival crevicular fluid were measured. In both groups, following clinical periodontal treatment, a statistically
significant decrease in white blood cells (WBC), low-density lipoproteins (LDL), fibrinogen, creatinine, and platelets
(PLT), a statistically significant increase in high-density lipoproteins (HDL) in blood samples, statistically meaningful
decrease in HBD-2, HBD-3, and calprotectin in the gingival crevicular fluid were achieved. Blood values and HBD-2,
HBD-3, calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared
to the control group. A positive correlation was observed between decreases in HBD-2, HBD-3, calprotectin, and
clinical periodontal indices. Regression in systemic inflammation was observed after clinical periodontal treatment. It
is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.},
DOI = {10.32604/biocell.2020.011470}
}