@Article{biocell.2020.08955,
AUTHOR = {MENGSHU ZHAO, PINGSHI GAO, LIANG TAO, JINGJING WEN, LEI WANG, YUGUO YI, YUXIN CHEN, JUNSONG WANG, XI XU, JIANFA ZHANG, DAN WENG},
TITLE = {Piceatannol attenuates streptozotocin-induced type 1 diabetes in mice},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {3},
PAGES = {353--361},
URL = {http://www.techscience.com/biocell/v44n3/40235},
ISSN = {1667-5746},
ABSTRACT = {As a natural analog of resveratrol, piceatannol (Pic) exhibits good antioxidant and anti-inflammatory activities in
different disease models. However, the role of Pic in type 1 diabetes mouse model has not been reported yet. In this study, we
investigated the <i>in vivo</i> effect of Pic in streptozotocin (STZ)-induced type 1 diabetic mice. Mice were injected with STZ to
establish the type 1 diabetes mellitus (T1DM) model. After stable hyperglycemia was achieved, mice were then orally treated
with Pic (40 mg/kg b.w., i.g.) for 30 days. The results indicated that Pic supplementation efficiently alleviated the typical
symptoms associated with T1DM, including body weight loss, polydipsia, hyperglycemia, and hypoinsulinemia. Pic
treatment also improved the glucose tolerance of STZ-induced diabetic mice. In addition, Pic supplementation markedly
decreased the expression of pro-inflammatory molecules TNF-α and IL-6, the expression of endoplasmic reticulum (ER)
stress markers GRP78 and CHOP, and the level of oxidative stress in T1DM mice. Moreover, Pic administration also
partly reversed the metabolic profiles of STZ-treated mice as detected by <sup>1</sup>
H Nuclear Magnetic Resonance (NMR)-based
metabolomics. Our study suggested that the therapeutic potential of Pic in type 1 diabetes and the anti-diabetic effects of
Pic may be associated with its activities to suppress oxidative stress, inflammation, and ER stress.},
DOI = {10.32604/biocell.2020.08955}
}