TY  - EJOU
AU  - CEJA-GÁLVEZ, HAZAEL RAMIRO 
AU  - TORRES-SÁNCHEZ, ERANDIS DHENI 
AU  - TORRES-JASSO, JUAN HERIBERTO 
AU  - ORNELAS, ARTURO VILLALOBOS 
AU  - SALAZAR-FLORES, JOEL 

TI  - Effect of structure and function of paraoxonase-1 (PON-1) on organophosphate pesticides metabolism
T2  - BIOCELL

PY  - 2020
VL  - 44
IS  - 3
SN  - 1667-5746

AB  - Paraoxonase-1 (PON1) is an important enzyme in various pathologies such as pesticide poisoning, diabetes,
atherosclerosis, neuronal disorders, and cancer, due to its multifunctional activity since it acts on different metabolites.
However, one of its main functions is the hydrolysis of organophosphate (OP) compounds from pesticides that cause
fatal poisoning at the level of the central nervous system (CNS). The objective of this review was to investigate whether
the structure, genetics, and function of PON1 affect the metabolism of organophosphate pesticides or other
abnormalities. Information was selected from articles in the database PubMed–NCBI (https://www.ncbi.nlm.nih.gov/
pubmed/) with a publication date between 2011 and 2019. The enzymatic activity of PON1 can be modified depending
on its chemical structure since there are different genetic polymorphisms that change PONI morphologies or the levels
of expression in the bloodstream. This leads to differences in susceptibilities to organophosphate pesticide poisoning.
The results of this review reveal that phenotypic variants of PON1 have differences in affinities for OP substrates.
KW  - PON1
KW  -  Pesticides
KW  -  Organophosphorus toxicity

DO  - 10.32604/biocell.2020.09147