@Article{biocell.2020.010257,
AUTHOR = {HAO WANG, FANG FANG, CHAOYI FANG, RUNSHENG ZHAO, SHAOXIAN WANG},
TITLE = {Changes in neuropeptides related to food intake in the rat arcuate nucleus after chronic immobilization stress and the effect of comfortable music exposure},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {3},
PAGES = {421--429},
URL = {http://www.techscience.com/biocell/v44n3/40242},
ISSN = {1667-5746},
ABSTRACT = {Stress is an inevitable interference factor that seriously affects health. Listening to music is an economical, noninvasive, and highly accepted tool for easing stress. However, physiological studies investigating the ability of music to
reduce stress in daily life are limited. We established rat models of chronic immobilization stress (CIS) to observe
changes in the hypothalamic arcuate nucleus (ARC) neurons involved in the regulation of food intake and the effect
of comfortable classical music exposure. Twenty-one days of stress resulted in decreased food intake and delayed body
weight gain; up-regulation of leptin receptor (Ob-R), cocaine- and amphetamine-regulated transcript (CART),
proopiomelanocortin (POMC), and alpha-melanocyte-stimulating hormone (α-MSH) expression; and downregulation of neuropeptide Y (NPY) and agouti-related protein (AgRP) expression in the ARC. Thus, peripheral leptin
entered the ARC under chronic stress conditions, bound to Ob-R, and affected downstream nerve pathways related to
appetite, such as the NPY/AgRP and CART/POMC pathways. Gentle classical music played at 65 dB reversed the
abnormal expression of Ob-R and NPY induced by chronic stress. Thus, listening to comfortable music improves
changes in ARC neurons related to the regulation of food intake in CIS rats, and these results provide a reference for
basic research regarding how music therapy alleviates stress and stress-related health issues.},
DOI = {10.32604/biocell.2020.010257}
}