TY  - EJOU
AU  - WANG, JIYU 
AU  - WANG, HUIPING 
AU  - PAN, YING 
AU  - TAO, QIANSHAN 
AU  - ZHAI, ZHIMIN 

TI  - Decreased CD10-positive granulocytes for the differential diagnosis of myelodysplastic syndrome
T2  - BIOCELL

PY  - 2020
VL  - 44
IS  - 4
SN  - 1667-5746

AB  - Myelodysplastic syndromes (MDS) are highly heterogeneous myeloid neoplasms, and a large number of
patients are difficult to diagnose and classify by blood and bone marrow examination. As a surface marker of
granulocyte, studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS patients.
However, whether it can be used for differential diagnosis of MDS and other hematological diseases remains
inconclusive. To explore the value of CD10 for differential diagnosis of MDS, 60 newly diagnosed MDS, 20 aplastic
anemia (AA) patients, and 35 iron-deficient anemia (IDA) patients were selected for this study. Bone marrow (BM)
specimens were processed for surface marker analysis and labeled with pre-conjugated monoclonal antibodies. Stained
cells were detected by flow cytometry. Our results indicated that CD10-positive granulocytes were significantly
decreased in BM of MDS patients than AA and IDA patients, and the level of CD10-positive mature granulocytes was
not associated with the clinical stages of malignancy. Receiver operating characteristic (ROC) areas under the curve
(AUC) of CD10-positive granulocytes was 0.86 and 0.85, respectively, in MDS patients than the IDA group and AA
group with good specificity and sensitivity. Further, CD10-positive granulocytes were increased after effective
treatment. In conclusion, we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS.
KW  - Myelodysplastic syndromes
KW  -  CD10
KW  -  Granulocytes
KW  -  Flow cytometry
KW  -  Differential diagnosis

DO  - 10.32604/biocell.2020.010947