@Article{biocell.2020.013053,
AUTHOR = {FANGHAO SUN, WENCHAO ZHAO, LIANSHENG ZHANG, HONGGUI MA, JIAN ZHOU, YOUGAN CHEN, JIANQUAN HOU},
TITLE = {Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancer progression},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {4},
PAGES = {639--647},
URL = {http://www.techscience.com/biocell/v44n4/40980},
ISSN = {1667-5746},
ABSTRACT = {Recent studies suggested that LIM and SH3 protein 1 (LASP-1) is a promising therapeutic target for renal cell
cancer (RCC). This study aimed to explore the role of LASP-1 in RCC. For this purpose, LASP-1 expression in RCC
tissues was analyzed by immunohistochemistry and Western blot analysis. Cell proliferation, migration, invasion, and
gene expression were detected by CCK-8 assay, Transwell assay, and Western blot analysis. The results showed that
LASP-1 was highly expressed in RCC, and its expression level,t was positively correlated with lymph node metastasis
and tumor, nodes, and metastases (TNM) stage. The knockdown of LASP-1 expression significantly inhibited the
proliferation of RCC cells, increased the apoptosis rate, and inhibited RCC cell invasion and migration by inhibiting
epithelial–mesenchymal transition. We conclude that LASP-1 promotes RCC progression and metastasis and is a
promising therapeutic target for RCC.},
DOI = {10.32604/biocell.2020.013053}
}