TY - EJOU AU - KUMAR, VIVEK AU - AGARWAL, VISHNU TI - COVID-19: Review on Its Etiology, Pathogenesis, and Existence in Humans T2 - BIOCELL PY - 2020 VL - 44 IS - 4 SN - 1667-5746 AB - The world is facing a new healthcare crisis with the rise and spread of novel coronavirus since December 2019. Also known as Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), the disease associated with SARSCoV-2 is even called COVID-19. The infection is said to have originated from the bat community and transmitted to humans through an intermediate host (yet unknown) in Wuhan, in the Hubei region of China. COVID-19 is having a pulverizing impact on the scientific community. As of August 13, 2020, the number of confirmed cases had reached up to 20,439,814 and the death toll to 744,385, affecting more than 188 territories across the globe. In these difficult times, the world is looking towards research and clinical work from different scientific communities to lead the way to a solution to the issue. In this review, we are focusing on COVID-19 emergence, pathogenicity, and existence in humans, as well as the SARS-CoV-2 infection mechanism and its similarities to previous coronavirus strains. KW - COVID-19 KW - SARS-CoV KW - MERS-CoV DO - 10.32604/biocell.2020.011090