@Article{biocell.2020.011638,
AUTHOR = {BICHUN ZHAO, XUEQING WU, YITONG YUAN, YUANTAO GAO, XIAO LI, RUOCHEN DU, SUMING XU, RUXIN ZHANG, CHUNFANG WANG},
TITLE = {Gene expression of granulosa and cumulus cells: The prospect in predicting the quality and developmental competence of oocytes <i>in vitro</i> maturation},
JOURNAL = {BIOCELL},
VOLUME = {44},
YEAR = {2020},
NUMBER = {4},
PAGES = {487--499},
URL = {http://www.techscience.com/biocell/v44n4/40996},
ISSN = {1667-5746},
ABSTRACT = {<i>In vitro</i> maturation (IVM), a promising assisted reproductive technology (ART), has been evolving in clinical
trials and applications. There is a huge potential demand for IVM in clinical practice because it reduces the stimulation of
gonadotropins to patients and provides evidence for the safety of neonatal birth. Unfortunately, the maturation rate of
oocytes <i>in vivo</i> is not as high as it is <i>in vivo</i> due to a different microenvironment. Moreover, there are still
controversies in predicting the developmental capability of oocytes in IVM. The granulosa cells (GCs) and cumulus
cells (CCs), closely surrounding the oocytes, play a critical role in oocytes development, while some studies have
shown that they can reflect the quality of oocytes. Many studies have been conducted in terms of oocyte quality in
transcriptional level in GCs and CCs of mice, <i>Xenopus africanus</i>, and <i>Homo sapiens</i>, which provides important
enlightenment for the successful clinical application of IVM. However, no comprehensive reviews about how gene
expression profiles affect oocytes quality have been reported. This review aimed to elucidate the gene expression
profiles of GCs and CCs that have effects on the quality and developmental competence of oocytes maturation in
vitro. And we also put forward a possible idea for ART in the future, integrating all gene expression profiles of GCs
and CCs and predicting the quality of the oocytes.},
DOI = {10.32604/biocell.2020.011638}
}