TY  - EJOU
AU  - SUN, TIECHENG 
AU  - SONG, LINGLI 
AU  - MA, JING 
AU  - YU, HONG 
AU  - ZHOU, SHANJIE 
AU  - WANG, SHUSONG 
AU  - TIAN, LI 

TI  - Melatonin and its protective role against male reproductive toxicity induced by heavy metals, environmental pollutants, and chemotherapy: A review
T2  - BIOCELL

PY  - 2020
VL  - 44
IS  - 4
SN  - 1667-5746

AB  - Melatonin, as a ubiquitous indoleamine hormone, is synthesized primarily by the pineal gland. It has diverse
biological effects through quite complex mechanisms. More recently, studies have focused on the mechanism of
melatonin in anti-reproductive toxicity/damage. Since melatonin possesses strong antioxidant and anti-apoptotic
properties, researchers have examined its potential role in protecting against male reproductive toxicity/damage,
which may be induced by chemotherapy or environmental toxicants and can lead to male infertility. In this article,
recent progress regarding the protective effects of melatonin on male reproductive toxicity/damage is reviewed.
KW  - Melatonin
KW  -  Membrane receptors
KW  -  Heavy metal
KW  -  Environmental toxicant
KW  -  Anti-reproductive toxicity

DO  - 10.32604/biocell.2020.011675