TY  - EJOU
AU  - MANOLE, EMILIA 
AU  - DUMITRESCU, LAURA 
AU  - NICULIȚE, CRISTINA 
AU  - POPESCU, BOGDAN OVIDIU 
AU  - CEAFALAN, LAURA CRISTINA 

TI  - Potential roles of functional bacterial amyloid proteins, bacterial biosurfactants and other putative gut microbiota products in the etiopathogeny of Parkinson’s Disease
T2  - BIOCELL

PY  - 2021
VL  - 45
IS  - 1
SN  - 1667-5746

AB  - An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its
potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative conditions.
The neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded
alpha-synuclein, known as Lewy bodies. Some gut microbiota products may trigger alpha-synuclein conformational
changes in the neurons of the enteric nervous system, which can then spread to the brain in a prion-like fashion
through the vagus nerve. Others may interfere with neuroinflammatory pathways and susceptibility to
neurodegeneration. In this review, we assess the potential role of putative gut microbiota products in the
etiopathogeny of Parkinson’s disease, with a special emphasis on functional bacterial amyloid proteins, bacterial
biosurfactants, endotoxins and short-chain fatty acids. The possible roles of molecular hydrogen, a common byproduct of bacterial fermentation, are also addressed.
KW  - Alpha-synuclein
KW  -  Endotoxins
KW  -  Short-chain fatty acids

DO  - 10.32604/biocell.2021.013452