@Article{biocell.2021.011827,
AUTHOR = {YAO QIAN, JINGPING WANG, ZIWAN JI, HAO CHEN, YUCANG HE, XULING LV, ZIKAI ZHANG, TIAN LI, TIANYUN PAN, LIQUN LI, MING LIN},
TITLE = {Acetyl-L-carnitine protects adipose-derived stem cells exposed to H<sub>2</sub>O<sub>2</sub> through regulating AMBRA1-related autophagy},
JOURNAL = {BIOCELL},
VOLUME = {45},
YEAR = {2021},
NUMBER = {1},
PAGES = {189--198},
URL = {http://www.techscience.com/biocell/v45n1/41412},
ISSN = {1667-5746},
ABSTRACT = {The cell activity of adipose-derived stem cells (ADSCs) is affected by the intracellular reactive oxygen species
(ROS) and the level of autophagy. Previous studies reveal that acetyl-L-carnitine (ALC) possesses capacities of resisting
oxidative stress and regulating autophagy. Activating molecule in Beclin1-regulated autophagy protein 1 (AMBRA1)
plays a key role in initiating Beclin1-regulated autophagy. In the present study, we discovered ALC pretreatment (1
mM, 24 h) significantly increased the activity of ADSCs exposed to H<sub>2</sub>O<sub>2</sub> (100 μM, 2 h) in vitro with improved
stemness, and reduced the production of intracellular ROS. In addition, we found for the first time that ALC
treatment up-regulated autophagy of ADSCs through strengthening the expressions of Beclin1 and AMBRA1
synchronously, which might be involved in the protective effect of ALC.},
DOI = {10.32604/biocell.2021.011827}
}