TY  - EJOU
AU  - MA, LIETING 
AU  - LI, MIAONG 
AU  - ZHENG, XINGLONG 

TI  - CircRNA ATF6 promotes ovarian cancer cell progression by activating PTEN/mTOR signaling pathway
T2  - BIOCELL

PY  - 2021
VL  - 45
IS  - 2
SN  - 1667-5746

AB  - Ovarian cancer is a malignant cancer type and affects women’s lives in the world. Circular RNAs (circRNAs)
have been involved with the progression of cancers. In our study, we are going to explore the functions of circATF6 in
ovarian cancer. The qRT-PCR assay was used to detect expressions of genes. Actinomycin D and RNase R treatment were
implemented to verify the circular RNA character of circATF6. Besides, Cell proliferation was assessed by colony
formation assay and EdU assay. Silenced circATF6 could reduce the proliferation of ovarian cancer cells. In addition,
inhibited circATF6 could promote the cell apoptosis and inhibit related proteins in PTEN/mTOR signaling pathway
in ovarian cancer. In conclusion, CircRNA ATF6 promotes ovarian cancer cell progression by activating PTEN/
mTOR signaling pathway.
KW  - CircRNA ATF6
KW  -  PTEN/mTOR signaling pathway
KW  -  Ovarian cancer

DO  - 10.32604/biocell.2020.09313