@Article{biocell.2021.014193,
AUTHOR = {HONG ZHOU, XIAOFENG JIA, FAN YANG},
TITLE = {Elevated nuclear phospho-eIF4E body levels are associated with tumor progression and poor prognosis for acute myeloid leukemia},
JOURNAL = {BIOCELL},
VOLUME = {45},
YEAR = {2021},
NUMBER = {3},
PAGES = {711--722},
URL = {http://www.techscience.com/biocell/v45n3/41680},
ISSN = {1667-5746},
ABSTRACT = {Uncontrolled proliferation is a hallmark of cancer cells, yet the molecular mechanisms that contribute to this
proliferation are unclear. Therapeutic treatment of cancer is suboptimal in many cases, with no accurate index by which
to evaluate the success of treatment or patient prognosis. In this study, we explored the protein levels of nuclear phosphoeIF4E in acute myeloid leukemia (AML) cell lines and primary leukemia samples by Western blot and
immunofluorescence and as well analyzed transcriptomes by RNA-seq. We found nuclear phospho-eIF4E, an exporter of
oncogenic mRNAs, to be abundant in AML. Further, nuclear phospho-eIF4E abundance was significantly associated with
tumor burden as well as the response of AML patients to chemotherapy. The results demonstrate “massive clustering and
export of oncogenic mRNAs to the translation machinery” by highly abundant RNA-nuclear phospho-eIF4E bodies. This
is an efficient mechanism that may drive the proliferation of cancer cells. Herein, nuclear phospho-eIF4E bodies were
identified as potential markers of AML, which may be useful for prognosis and as targets for cancer therapy.},
DOI = {10.32604/biocell.2021.014193}
}