TY  - EJOU
AU  - MARTINS, AMYLLY SANUELLY DA PAZ 
AU  - CAMPOS, SAMARA BOMFIM GOMES 
AU  - GOULART, MARÍLIA OLIVEIRA FONSECA 
AU  - MOURA, FABIANA ANDRÉA 

TI  - Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?
T2  - BIOCELL

PY  - 2021
VL  - 45
IS  - 3
SN  - 1667-5746

AB  - Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, has a not yet
completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative
stress and dysbiosis. Extraintestinal manifestations can occur and affect several organs, including the liver and bile
ducts, joints, skin, eyes, and less frequently, the heart, brain, and kidneys, increasing the risk of morbidity and
mortality. These repercussions may be associated with the activity or severity of IBD. The present review proposes to
report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal
manifestations, aiming to contribute to a better understanding of the disease and to focus on the development of
individualized preventive and therapeutic strategies.
KW  - Oxidative stress
KW  -  Microbiota
KW  -  Bacterial translocation
KW  -  Ulcerative colitis
KW  -  Crohn disease

DO  - 10.32604/biocell.2021.014332