@Article{biocell.2021.013864,
AUTHOR = {LIN LIU, ZHOUWEN XU, YUYAN JIANG, MD REZAUL KARIM, XIAO HUANG},
TITLE = {Cell cycle regulation through primary cilium: A long-forgotten story},
JOURNAL = {BIOCELL},
VOLUME = {45},
YEAR = {2021},
NUMBER = {4},
PAGES = {823--833},
URL = {http://www.techscience.com/biocell/v45n4/42355},
ISSN = {1667-5746},
ABSTRACT = {Protruded from cytomembrane, primary cilium is a widespread cell organelle that can be found in almost all cell
types in Mammalia. Because of its comprehensive requirement in various cellular activities and various functions in
different organs, primary cilium has been a valuable research area of human pathology research since the turn of the
millennium. And the potential application of the interaction between primary cilia and cell cycle regulation may be
the most promising direction as many primary cilium-caused diseases are found to be caused by cell cycle
dysregulation resulted from primary cilia defects. Therefore, a deep understanding of the interaction between primary
cilia and the cell cycle is in great need. Hence in this review, we mainly described how the interaction between
primary cilia and cell cycle proceeds and demonstrated three hypotheses raised from much different research. These
hypotheses include (1) Primary cilium as a cellular signaling hub to regulate the cell cycle, (2) Primary cilium as a
reservoir of cell cycle regulation-related factors, and (3) Primary cilium as a cell cycle checkpoint or a brake.
Nonetheless, we also call for more attention on research of interaction between cell cycle and primary cilia and tried
to point out some possible research directions for those who are interested.},
DOI = {10.32604/biocell.2021.013864}
}