@Article{biocell.2021.014280,
AUTHOR = {JIYU WANG, YING PAN, YANG WAN, ZHIXIANG WANYAN, ZHITAO WANG, QIANSHAN TAO, ZHIMIN ZHAI},
TITLE = {<i>SENEX</i> gene promotes cell proliferation by activating RB/E2F pathway in diffuse large B-cell lymphoma cells},
JOURNAL = {BIOCELL},
VOLUME = {45},
YEAR = {2021},
NUMBER = {4},
PAGES = {933--942},
URL = {http://www.techscience.com/biocell/v45n4/42364},
ISSN = {1667-5746},
ABSTRACT = {The present study aimed to clarify the role of <i>SENEX</i> in malignant cell proliferation in diffuse large B-cell
lymphoma (DLBCL). 22 DLBCL patients (6 newly diagnosed cases, 7 cases at complete remission, and 9 relapsed
cases) were included in the study. Our results indicated that both <i>SENEX</i> gene and protein were significantly
increased in peripheral blood mononuclear cells (PBMCs) and tumor cells of relapsed DLBCL patients, accompanied
by overexpression of p21, p16, and phosphorylated retinoblastoma (Rb). Silencing the <i>SENEX</i> gene in a DLBCL cell
line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1 phase.
Phosphorylated Rb and E2F1 were also decreased, and activation of the Rb/E2F1 pathway was obviously suppressed.
To conclude, the <i>SENEX</i> gene promotes proliferation in PBMC and tumor cells of DLBCL patients by activating the
Rb/E2F1 pathway, in a manner suggesting that increased <i>SENEX</i> expression affects the relapse of DLBCL and may
serve as an important target for DLBCL therapy.},
DOI = {10.32604/biocell.2021.014280}
}