@Article{biocell.2021.014900,
AUTHOR = {HAORAN SU, KEXIN LI, XIAO LIU, JING DU, LI WANG, XIAOYAN DENG, YUBO FAN},
TITLE = {Microfluidic chips for the endothelial biomechanics and mechanobiology of the vascular system},
JOURNAL = {BIOCELL},
VOLUME = {45},
YEAR = {2021},
NUMBER = {4},
PAGES = {797--811},
URL = {http://www.techscience.com/biocell/v45n4/42370},
ISSN = {1667-5746},
ABSTRACT = {Endothelial cells arranged on the vessel lumen are constantly stimulated by blood flow, blood pressure and pressureinduced cyclic stretch. These stimuli are sensed through mechanical sensory structures and converted into a series of
functional responses through mechanotransduction pathways. The process will eventually affect vascular health. Therefore,
there has been an urgent need to establish <i>in vitro</i> endothelial biomechanics and mechanobiology of models, which
reproduce three-dimensional structure vascular system. In recent years, the rapid development in microfluidic technology
makes it possible to replicate the key structural and functionally biomechanical characteristics of vessels. Here, we
summarized the progress of microfluidic chips used for the investigation of endothelial biomechanics and mechanobiology
of the vascular system. Firstly, we elucidated the contribution of shear stress and circumferential stress, to vascular
physiology. Then, we reviewed some applications using microfluidic technology in angiogenesis and vasculogenesis,
endothelial permeability and mechanotransduction, as well as the blood-brain barrier under these physical forces. Finally,
we discussed the future obstacles in terms of the development and application of microfluidic vascular chips.},
DOI = {10.32604/biocell.2021.014900}
}