@Article{biocell.2021.015836,
AUTHOR = {CHUNJIAO LIU, QINHONG KONG, FENG PAN, SHAN JIANG, LINGJIE MENG, GAI HUANG, LIDAN LU, SANHUA LI, YUN LIU,3},
TITLE = {Hellebrigenin induces apoptosis in colorectal cancer Cells through induction of excessive reactive oxygen species},
JOURNAL = {BIOCELL},
VOLUME = {45},
YEAR = {2021},
NUMBER = {4},
PAGES = {943--951},
URL = {http://www.techscience.com/biocell/v45n4/42374},
ISSN = {1667-5746},
ABSTRACT = {Traditional Chinese medicine (TCM) has been increasingly applied in both preventing and treating a variety of
cancers in the last decades, attributing to its fewer side effects as compared with chemotherapy drugs. Hellebrigenin, a
component of Chanpi from the skin of Bufo bufogargarizans Cantor or Duttaphrynus melanostictus has been reported
to have an obvious anti-cancer activity on various cancers. However, the effect and mechanism of hellebrigenin on
colorectal cancers were still unknown. Herein, the present study demonstrated hellebrigenin significantly reduced
viability and triggered apoptosis via the intrinsic pathway in colorectal cancer cell lines HCT116 and HT29 in vitro
and in vivo. Moreover, hellebrigenin led to a reduction of mitochondrial membrane potential. In addition, treatment
with hellebrigenin could result in the induction of excessive reactive oxygen species, which led to cell apoptosis. These
results indicated that hellebrigenin had anti-cancer potential in the treatment of colorectal cancers.},
DOI = {10.32604/biocell.2021.015836}
}