@Article{biocell.2021.015323,
AUTHOR = {BARKAT ALI KHAN, FAZAL KARIM, MUHAMMAD KHALID KHAN, FAHEEM HAIDER, SADIQULLAH KHAN},
TITLE = {Synthesis and characterization of polymeric responsive CMC/Pectin hydrogel films loaded with <i>Tamarix aphylla</i> extract as potential wound dressings},
JOURNAL = {BIOCELL},
VOLUME = {45},
YEAR = {2021},
NUMBER = {5},
PAGES = {1273--1285},
URL = {http://www.techscience.com/biocell/v45n5/43081},
ISSN = {1667-5746},
ABSTRACT = {The fourth most predominant overwhelming type of trauma is burn injuries worldwide. Ideal wound healing
dressings help in the wound healing process in a lower time with less pain. Commonly used dry wound dressing, like
absorbent gauze or absorbent cotton, possess limited therapeutic effects and require repeated use, which further
exaggerates patients’ suffering. In contrast, hydrogels films present a promising alternative to improve healing by
guaranteeing a moisture balance at the wound site. The aim of the current study was to synthesize <i>Tamarix aphylla</i>
(<i>T. aphylla</i>) extract-loaded hydrogel film with Na-CMC and pectin and to study their wound healing properties. The
Na-CMC/Pectin hydrogels films were synthesized and characterized for HPLC analysis, FTIR, surface morphology,
rheology, tensile strength, swelling behavior, drug release kinetics, and <i>in vivo</i> wound healing in an animal model.
FTIR confirmed the existence of strong interaction between both polymers but no interaction with the extract. SEM
photographs showed successful embedding of extract in small pores of hydrogel film and showed smooth and
homogenous morphology. Rheological and texture profiles indicated that hydrogels behaved as strong gels. Swelling
and erosion were dependent on the amount of the CMC. HPLC showed drug content of three selected formulation
(A3, E3 and S3) as 85 ± 0.1%, 82.5 ± 0.4% and 80 ± 0.3%, respectively. The release of the drug from the hydrogel was
controlled by a Fickian diffusion mechanism.<i> In vivo</i> wound healing activity of hydrogel film confirmed that
<i>T. aphylla</i> extract successfully promoted healing rate by significantly reducing (<i>P</i> < 0.05) the size of wound closure
compared to the control group, evidenced by intensive collagen formation in histopathological and biochemical
analysis. The capability of these hydrogels for burn wounds could be valuable for medical uses as a new window of
safe and effective medication.},
DOI = {10.32604/biocell.2021.015323}
}