TY  - EJOU
AU  - HAN, XIAOMEI 
AU  - ZHANG, SHUYING 
AU  - WANG, YIFU 
AU  - QI, CHANGE 
AU  - GUO, PENGNYU 
AU  - XU, YALI 
AU  - LYU, GUANGHUI 

TI  - The signaling pathway in modulating bone metabolism after dental implant in diabetes
T2  - BIOCELL

PY  - 2021
VL  - 45
IS  - 6
SN  - 1667-5746

AB  - Diabetes Mellitus is a systematic disease with complications in multi-organs, including decreased implant osseointegration and a high failure rate of dental transplants. Accumulating evidence indicates that the signaling pathway directly impacts the process of bone metabolism and inflammatory response implicated with dental implants in diabetic patients. This review summarizes the recent advance in signaling pathways regulate osseointegration and inflammatory response in dental transplantation, aiming to identify the potential therapeutic target to reduce the dental transplant failure in diabetes patients, with emphasis on the surface characteristics of the implant, inflammatory signaling, AMPK, PPARγ, WNT, ROS, and adiponectin signaling.
KW  - Diabetes; Osseointegration; Titanium; Wnt; ROS; Adiponectin; PPARγ; Dental transplant

DO  - 10.32604/biocell.2021.09506