@Article{biocell.2022.016509,
AUTHOR = {YANYAN LI, SHAHANAVAJ KHAN, ANIS AHMAD CHAUDHARY, HASSAN AHMED RUDAYNI, ABDUL MALIK, ASHWAG SHAMI},
TITLE = {Proteome-wide screening for the analysis of protein targeting of <i>Chlamydia pneumoniae</i> in endoplasmic reticulum of host cells and their possible implication in lung cancer development},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {1},
PAGES = {87--95},
URL = {http://www.techscience.com/biocell/v46n1/44752},
ISSN = {1667-5746},
ABSTRACT = {Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the <i>Chlamydia pneumonia</i> proteins targeting in endoplasmic reticulum (ER) using <i>in-silico</i> approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed <i>C. pneumoniae</i> proteins targeting human ER and their implications in lung cancer growth. These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the usual pathway functions and trigger the development of lung cancer. Moreover, <i>C. pneumoniae</i> unfolded protein accumulation in the human ER possibly induces ER stress, consequently activating the unfolded protein response (UPR), and providing a favorable microenvironment for cancer growth. The current study showed the <i>C. pneumoniae</i> protein targeting in ER of host cell and their implication in lung cancer growth. These results may help researchers better manage lung cancer and establish a molecular mechanism for <i>C. pneumoniae</i> lung cancer association.},
DOI = {10.32604/biocell.2022.016509}
}