TY  - EJOU
AU  - THAKUR, SALONI 
AU  - SAINI, ADESH K. 
AU  - DAS, JOYDEEP 
AU  - SAINI, VIPIN 
AU  - BALHARA, PARIN 
AU  - NANDA, JAGPREET S. 
AU  - SAINI, REENA V. 

TI  - miR-153 as biomarker for cancer—functional role as tumor suppressor
T2  - BIOCELL

PY  - 2022
VL  - 46
IS  - 1
SN  - 1667-5746

AB  - MicroRNA-153 (miR-153), belongs to a class of small non-coding RNA. It is a critical regulator of gene expression at the post-transcriptional level which interacts with the functional mRNA at 3’UTR region and suppresses the expression of the mRNA. More recently, it has become apparent that changes in the miR-153 expression lead to invasion, metastasis, angiogenesis and various types of tumor progression. This review summarizes the connection between dysregulation of miR-153 and various types of cancer progression. miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the cancer cell and also show synergistic activity with anticancer drugs. In addition to this, the oncogenic behavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.
KW  - Biomarker; Cancer; miR-153; Oncogenic; Tumor suppressor

DO  - 10.32604/biocell.2022.016953