@Article{biocell.2021.016253,
AUTHOR = {JIANFEI GAO, KANGNING XIONG, WEIJIE LI, WEI ZHOU},
TITLE = {Differential metabolome landscape of <i>Kadsura coccinea</i> fruit tissues and potential valorization of the peel and seed tissues},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {1},
PAGES = {285--296},
URL = {http://www.techscience.com/biocell/v46n1/44768},
ISSN = {1667-5746},
ABSTRACT = {<i>Kadsura coccinea</i> (Lem.) is a woody wine plant with a peculiar fruit enriched in important health-promoting
compounds. The non-editable part of the fruit, i.e., the seed and peel, represents more than 60% of the fruit and is
considered a biowaste. This significantly restricts the development of the <i>K. coccinea</i> fruit industry. Clarifying the
metabolic components of the different fruit parts can help to improve the utilization rate and valorization of
<i>K. coccinea</i>. Herein, we evaluated <i>K. coccinea</i> fruit peel, pulp, and seed using widely-targeted metabolomics and
quantified a set of 736 bioactive compounds from 11 major metabolite classes. The most prominent metabolite classes
included lipids, amino acids, flavonoids, and lignans. Furthermore, our results emphasized a significant accumulation
of flavonoids in pulp tissues, while alkaloids and lignans were abundant in peel and seed tissues, respectively. A total
of 183 metabolites were differentially accumulated among the three tissues. Procyanidin C2, rutinoside,
2-hydroxyoleanolic acid, 5-hydroxymethyluracil, nootkatol, isoquercitrin, isohyperoside, quercetin-7-O-glucoside,
hyperin, and rutin showed elevated accumulation in the peel. In the seed, kadsuralignan G, kadcoccilactone A,
kadsuralignan H, lysoPE 20:5, iso-schisandrin ethyl alcohol, and kadangustin were significantly enriched. Our results
highlight the diverse metabolome composition of <i>K. coccinea</i> fruit parts, which can be further exploited for its
valorization in various industries.},
DOI = {10.32604/biocell.2021.016253}
}