@Article{biocell.2022.021150,
AUTHOR = {FABIANO BINI, ANDRADA PICA, ANDREA MARINOZZI, FRANCO MARINOZZI},
TITLE = {A nanostructured look of collagen apatite porosity into human mineralized collagen fibril},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {10},
PAGES = {2225--2229},
URL = {http://www.techscience.com/biocell/v46n10/48224},
ISSN = {1667-5746},
ABSTRACT = {Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring
structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in
determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to
maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several
analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the
fine replication of the natural tissue still represents a challenge. Insights on the structural organization at nanoscale
and on the influence of apatite mineral crystals on the diffusion coefficient lead to outline the functional conditions
for the development of biomimetic strategies for bone tissue engineering. Thorough understanding of bone
nanostructure is essential to improve longevity of bioscaffolds and to decrease the risk of failure by controlling their
mechanical and biological performance.},
DOI = {10.32604/biocell.2022.021150}
}