@Article{biocell.2022.021032,
AUTHOR = {LING SHENG, YUEHONG SHEN, HONGYU YANG},
TITLE = {Effect of demethyltransferase FTO on tumor progression},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {11},
PAGES = {2387--2397},
URL = {http://www.techscience.com/biocell/v46n11/48772},
ISSN = {1667-5746},
ABSTRACT = {<i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification is the most widespread and conserved internal mRNA modification in mammalian cells. It greatly affects genetic regulation by enhancing the involvement of diverse cellular enzymes and thus, plays a significant role in basic life processes. Numerous studies on m<sup>6</sup>A modification identified FTO as a crucial demethylase that participates in various biological processes. Not only does FTO play a pivotal role in obesity-related conditions, but it also influences the occurrence, development, and prognosis of several cancers, such as acute myeloid leukemia, breast cancer, liver cancer, and lung cancer. Moreover, FTO also shows a close association with immunity and viral infections. This article summarized the molecular mechanism of FTO in tumorigenesis and tumor progression.},
DOI = {10.32604/biocell.2022.021032}
}