TY - EJOU
AU - BORA, EJDER SAYLAV
AU - ERDOĞAN, MüMIN ALPER
AU - ÖZKUL, BAHATTIN
AU - SEVER, İBRAHIM HALIL
AU - SÖĞÜT, İBRAHIM
AU - HÜRDAĞ, CANAN
AU - ERBAŞ, OYTUN
TI - Short term protective effect of digitoxin in sepsis-induced acute lung injury
T2 - BIOCELL
PY - 2022
VL - 46
IS - 2
SN - 1667-5746
AB - Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known anti-inflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury (ALI). Method: 28 wistar albino rats were divided into 4 groups. Sepsis model is performed by the feces intraperitoneal-injection procedure (FIP). Results: TNF-a, CRP, IL-6, IL 1-Beta, lactic acid, and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group. When the same groups were examined, histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group. Conclusion: Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action, and healing effects in both computerized tomography and histology in the lung.
KW - Digitoxin; Animal model; Sepsis; Acute lung injury
DO - 10.32604/biocell.2022.018510