@Article{biocell.2022.016848, AUTHOR = {ABDELKADER HASSANI, SITI ASLINA HUSSAIN, MOTHANNA SADIQ AL-QUBAISI, MOHAMED LAKHDER BELFAR, HAKIM BELKHALFA, HAMID HAMMAD ENEZEI, HAMID ZENTOU, WISAM NABEEL IBRAHIM, ABD ALMONEM DOOLAANEA}, TITLE = {Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells}, JOURNAL = {BIOCELL}, VOLUME = {46}, YEAR = {2022}, NUMBER = {3}, PAGES = {677--687}, URL = {http://www.techscience.com/biocell/v46n3/45624}, ISSN = {1667-5746}, ABSTRACT = {The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of –15 mV. The Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500 µg/mL. The Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations used. Hence, the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of Curcumin. Therefore, Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.}, DOI = {10.32604/biocell.2022.016848} }