TY - EJOU AU - HASSANI, ABDELKADER AU - HUSSAIN, SITI ASLINA AU - AL-QUBAISI, MOTHANNA SADIQ AU - BELFAR, MOHAMED LAKHDER AU - BELKHALFA, HAKIM AU - ENEZEI, HAMID HAMMAD AU - ZENTOU, HAMID AU - IBRAHIM, WISAM NABEEL AU - DOOLAANEA, ABD ALMONEM TI - Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells T2 - BIOCELL PY - 2022 VL - 46 IS - 3 SN - 1667-5746 AB - The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of –15 mV. The Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500 µg/mL. The Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations used. Hence, the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of Curcumin. Therefore, Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension. KW - Curcumin; Gum arabic; Nanoparticles; Cancer cells; Antioxidants DO - 10.32604/biocell.2022.016848