@Article{biocell.2022.017757,
AUTHOR = {TIANTIAN XU, RUILIN ZHENG, DANYANG CHEN, HAIYANG CHEN, MINGQI ZHAO, MIN GUO, YI CHEN, CHANGBING WANG, LU KUANG, YINGHUA LI, BING ZHU},
TITLE = {Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {4},
PAGES = {1033--1039},
URL = {http://www.techscience.com/biocell/v46n4/45979},
ISSN = {1667-5746},
ABSTRACT = {Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor that can prevent apoptosis. The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs. In this study, after treated with ZVAD in EV-A71 infected Vero cells, the viral replication was reduced, and the cell viability was higher than EV-A71 group. Additionally, ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells. ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral.},
DOI = {10.32604/biocell.2022.017757}
}