TY  - EJOU
AU  - XU, TIANTIAN 
AU  - ZHENG, RUILIN 
AU  - CHEN, DANYANG 
AU  - CHEN, HAIYANG 
AU  - ZHAO, MINGQI 
AU  - GUO, MIN 
AU  - CHEN, YI 
AU  - WANG, CHANGBING 
AU  - KUANG, LU 
AU  - LI, YINGHUA 
AU  - ZHU, BING 

TI  - Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways
T2  - BIOCELL

PY  - 2022
VL  - 46
IS  - 4
SN  - 1667-5746

AB  - Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor that can prevent apoptosis. The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs. In this study, after treated with ZVAD in EV-A71 infected Vero cells, the viral replication was reduced, and the cell viability was higher than EV-A71 group. Additionally, ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells. ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral.
KW  - ZVAD; EV-A71 virus; ROS; Apoptosis

DO  - 10.32604/biocell.2022.017757