@Article{biocell.2022.018391,
AUTHOR = {M. CAROLINA DI SANTO, AGUSTINA ALAIMO, ANA PAULA DOMÍNGUEZ RUBIO, OSCAR E. PÉREZ},
TITLE = {Impact of chitosan-based nanocarriers on cytoskeleton dynamics: Current status and challenges},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {4},
PAGES = {885--891},
URL = {http://www.techscience.com/biocell/v46n4/45990},
ISSN = {1667-5746},
ABSTRACT = {Chitosan-based nanocarriers (CS-NCs) show a promising role in improving drugs and bioactive compounds delivery for therapy. However, the effects exerted by CS-NCs at the cellular level, including their recognition and uptake, have not been fully investigated yet. Many factors, including size, shape, concentration, and surface chemistry of CS-NCs, play an important role in determining the types of intracellular signals triggered. The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells. In the present work, we discuss the effects induced by CS-NCs  per se on the cytoskeleton, a key component in cell architecture and physiology. The focus of this report is made on tumoral and normal biological models in which CS-NCs could differentially affect the cell cytoskeleton. The recent years reports regarding the impact of CS-NCs on cytoskeleton dynamics and the current techniques for its evaluation are summarized and discussed. Understanding mechanisms underlying cytoskeletal impact after cell exposure to CS-NCs is critical for the design of safest value-added formulations in the biomedical field. Furthermore, this revision points out some interesting aspects of cytoskeletal changes and cell death encompassing anti-tumoral effects.},
DOI = {10.32604/biocell.2022.018391}
}