@Article{biocell.2022.018960,
AUTHOR = {YUKI MATSUSHITA, WANIDA ONO, NORIAKI ONO},
TITLE = {Synergy of single-cell sequencing analyses and <i>in vivo</i> lineage-tracing approaches: A new opportunity for stem cell biology},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {5},
PAGES = {1157--1162},
URL = {http://www.techscience.com/biocell/v46n5/46196},
ISSN = {1667-5746},
ABSTRACT = {Single-cell sequencing technologies have rapidly progressed in recent years, and been applied to characterize stem cells in a number of organs. Somatic (postnatal) stem cells are generally identified using combinations of cell surface markers and transcription factors. However, it has been challenging to define micro-heterogeneity within “stem cell” populations, each of which stands at a different level of differentiation. As stem cells become defined at a single-cell level, their differentiation path becomes clearly defined. Here, this viewpoint discusses the potential synergy of single-cell sequencing analyses with <i>in vivo</i> lineage-tracing approaches, with an emphasis on practical considerations in stem cell biology.},
DOI = {10.32604/biocell.2022.018960}
}