@Article{biocell.2022.017609,
AUTHOR = {WEI LI, YUEYANG DUAN, XIAOTONG YAN, XIANGXIANG LIU, MEILING FAN, ZI WANG},
TITLE = {A mini-review on pharmacological effects of ginsenoside Rb3, a marked saponin from <i>Panax genus</i>},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {6},
PAGES = {1417--1423},
URL = {http://www.techscience.com/biocell/v46n6/46682},
ISSN = {1667-5746},
ABSTRACT = {Ginsenoside Rb3 (G-Rb3) is one of the primary active compounds isolated from <i>Panax ginseng</i> Meyer, which belongs to protopanaxadiol ginsenosides (PPD). Based on the structure-activity relationship (SAR) of ginsenosides, the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent. However, pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins, such as Compound K, F2, etc. A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials, which was achieved by diminishing oxidative stress and apoptosis. Therefore, more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical applications. This article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development.},
DOI = {10.32604/biocell.2022.017609}
}