TY - EJOU
AU - LI, WEI
AU - DUAN, YUEYANG
AU - YAN, XIAOTONG
AU - LIU, XIANGXIANG
AU - FAN, MEILING
AU - WANG, ZI
TI - A mini-review on pharmacological effects of ginsenoside Rb3, a marked saponin from Panax genus
T2 - BIOCELL
PY - 2022
VL - 46
IS - 6
SN - 1667-5746
AB - Ginsenoside Rb3 (G-Rb3) is one of the primary active compounds isolated from Panax ginseng Meyer, which belongs to protopanaxadiol ginsenosides (PPD). Based on the structure-activity relationship (SAR) of ginsenosides, the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent. However, pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins, such as Compound K, F2, etc. A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials, which was achieved by diminishing oxidative stress and apoptosis. Therefore, more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical applications. This article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development.
KW - Ginsenoside Rb3; Pharmacological effects; Review; Signaling pathway
DO - 10.32604/biocell.2022.017609