TY - EJOU AU - LI, WEI AU - DUAN, YUEYANG AU - YAN, XIAOTONG AU - LIU, XIANGXIANG AU - FAN, MEILING AU - WANG, ZI TI - A mini-review on pharmacological effects of ginsenoside Rb3, a marked saponin from Panax genus T2 - BIOCELL PY - 2022 VL - 46 IS - 6 SN - 1667-5746 AB - Ginsenoside Rb3 (G-Rb3) is one of the primary active compounds isolated from Panax ginseng Meyer, which belongs to protopanaxadiol ginsenosides (PPD). Based on the structure-activity relationship (SAR) of ginsenosides, the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent. However, pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins, such as Compound K, F2, etc. A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials, which was achieved by diminishing oxidative stress and apoptosis. Therefore, more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical applications. This article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development. KW - Ginsenoside Rb3; Pharmacological effects; Review; Signaling pathway DO - 10.32604/biocell.2022.017609