@Article{biocell.2022.018326,
AUTHOR = {YANG YANG, BENSHUAI YOU, CHENGLIN ZHOU},
TITLE = {Effect of VirD4 on gastric epithelial-1 cells and its mechanism},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {6},
PAGES = {1557--1564},
URL = {http://www.techscience.com/biocell/v46n6/46686},
ISSN = {1667-5746},
ABSTRACT = {The gene of <i>Helicobacter pylori</i> can encode three to four type IV secretory systems, of which a new gene region has been found in the <i>H. pylori</i> plasticity region. The coding products of this region can form a new T4SS named tfs3, but its function is unclear. This study investigated the effect of VirD4 recombinant protein in the tfs3 secretory system of the <i>H. pylori</i> clinical strain SBK on GES-1 cells. We observed changes in cell morphology after VirD4 treatment. Further analysis indicated that VirD4 increased inflammation by increasing the activation of NF-κB. VirD4 can also inhibited proliferation, and induced migration of cells. Moreover, VirD4 caused apoptosis in GES-1 cells in caspase and ERK1/2/Ras dependent signaling events. Our study laid a foundation for further research on the biological function of VirD4 and the detection and treatment of <i>H. pylori</i>-related diseases.},
DOI = {10.32604/biocell.2022.018326}
}