TY  - EJOU
AU  - YANG,  
AU  - YOU, BENSHUAI 
AU  - ZHOU, CHENGLIN 

TI  - Effect of VirD4 on gastric epithelial-1 cells and its mechanism
T2  - BIOCELL

PY  - 2022
VL  - 46
IS  - 6
SN  - 1667-5746

AB  - The gene of <i>Helicobacter pylori</i> can encode three to four type IV secretory systems, of which a new gene region has been found in the <i>H. pylori</i> plasticity region. The coding products of this region can form a new T4SS named tfs3, but its function is unclear. This study investigated the effect of VirD4 recombinant protein in the tfs3 secretory system of the <i>H. pylori</i> clinical strain SBK on GES-1 cells. We observed changes in cell morphology after VirD4 treatment. Further analysis indicated that VirD4 increased inflammation by increasing the activation of NF-κB. VirD4 can also inhibited proliferation, and induced migration of cells. Moreover, VirD4 caused apoptosis in GES-1 cells in caspase and ERK1/2/Ras dependent signaling events. Our study laid a foundation for further research on the biological function of VirD4 and the detection and treatment of <i>H. pylori</i>-related diseases.
KW  - <i>H. pylori</i>; tfs3; VirD4; NF-κB; Ras/Erk

DO  - 10.32604/biocell.2022.018326