TY  - EJOU
AU  - SWANSON, W. BENTON 
AU  - MISHINA, YUJI 

TI  - New paradigms in regenerative engineering: Emerging role of extracellular vesicles paired with instructive biomaterials
T2  - BIOCELL

PY  - 2022
VL  - 46
IS  - 6
SN  - 1667-5746

AB  - Mesenchymal stem cells (MSCs) have long been regarded as critical components of regenerative medicine strategies, given their multipotency and persistence in a variety of tissues. Recently, the specific role of MSCs in mediating regenerative outcomes has been attributed (in part) to secreted factors from transplanted cells, namely extracellular vesicles. This viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration, enhanced by synergy with appropriate biomaterials platforms. Extracellular vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and biomaterials. As a result, we believe these technologies will improve patient outcomes through efficient therapeutic strategies resulting in predictable patient outcomes.
KW  - Biomaterials; Extracellular vesicles; Mesenchymal stem cells; Regenerative medicine; Tissue engineering

DO  - 10.32604/biocell.2022.018781